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. 2017 Sep 25;29(1):223–229. doi: 10.1093/annonc/mdx542

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© The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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Figure 1. — Cancer-specific exosomal biomarker selection and validation. (A) Heat map representation of proteins that are expressed on the surface of pancreatic ductal adenocarcinoma exosomes that are not expressed (or expressed at very low levels) on the surface of HPNE and CAF19 exosomes. (B) Western blot validation of identified candidate biomarkers: protein expression analysis of cell lysates (left) compared with exosomes (right) of neoplastic (Pa01C, Pa03C, and Pa04C) and non-neoplastic (CAF19 and SC2) cell lines. CD63 and TSG101 are used as antibody controls for identification of exosome populations. Most selected biomarkers show enriched specificity towards being present in cancer exosomes versus normal exosomes.