Table 3.

Relative Infection Hazard by Neighborhood Socioeconomic Status Score

nSES Score Quartile	Infections, No. (%)	Infection Incidence per 1000 PY (95% CI)	Crude	Add Race	Add Other Demographicsa	Add Behaviorsb + Chronic Conditionsc + Biomarkersd	Add Functional Statuse
			HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
Q1: –11.79 to –3.90 [Lowest]	605 (9.1)	15.6 (14.4–16.9)	Ref	Ref	Ref	Ref	Ref
Q2: –3.89 to –0.93	630 (9.5)	15.7 (14.5–17.0)	1.00 (.90–1.12)	0.90 (.81–1.01)	0.96 (.86–1.08)	1.00 (.89–1.12)	1.01 (.90–1.14)
Q3: –0.92 to 3.08	585 (8.8)	14.0 (12.9–15.2)	0.89 (.80–1.00)	0.76 (.68–.86)	0.85 (.75–.96)	0.93 (.82–1.06)	0.94 (.83–1.07)
Q4: 3.09–28.95 [Highest]	505 (7.6)	11.7 (10.7–12.8)	0.74 (.66–0.84)	0.59 (.52–.68)	0.68 (.60–.78)	0.81 (.70–.93)	0.84 (.73–.97)
Trend P value			<.001	<.001	<.001	.002	.011

Total of 26604 Reasons for Geographic and Racial Differences in Stroke (REGARDS) participants. HRs estimated using Cox proportional hazards regression. P values represent tests for linear trends across nSES score quartiles.

Abbreviations: CI, confidence interval; HR, hazard ratio; nSES, neighborhood socioeconomic status; PY, person-years.

^aAge, gender, region, income, and education.

^bSmoking status and alcohol use.

^cBody mass index category, chronic lung disease, diabetes, hypertension, myocardial infarction, and stroke.

^dHigh-sensitivity C-reactive protein and estimated glomerular filtration rate.

^eWeakness, exhaustion, and low physical activity.