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. 2017 Nov 14;29(2):466–471. doi: 10.1093/annonc/mdx736

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© The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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Figure 1. — EGFR mutations and HPV infection are essential, mutually exclusive oncogenic events in inverted sinonasal papillomas and associated sinonasal squamous cell carcinomas. Frequency of EGFR mutations (blue), low-risk HPV DNA (green), and high-risk HPV DNA (red) in inverted sinonasal papilloma (ISP), ISP-associated sinonasal squamous cell carcinoma (ISP-Assoc. SNSCC) and sinonasal squamous cell carcinoma without a known ISP associated [SNSCC (Not ISP-Assoc.)]. A single case of ISP demonstrated both an EGFR mutation and transient, low-level HPV DNA that likely reflects incidental HPV colonization (light green). HPV subtype was unknown for one SNSCC (Not ISP-Assoc.; yellow).