Table 2.
Clinicopathologic characteristics of sinonasal squamous cell carcinoma (SNSCC), stratified by inverted sinonasal (Schneiderian) papilloma (ISP) association
| Clinicopathologic parameter | ISP-associated SNSCC (n = 22) | SNSCC without known ISP association (n = 14) | P-value | |
|---|---|---|---|---|
| Age at initial diagnosis (years) | Mean | 53.8 | 61.9 | 0.006 |
| Median | 54 | 65 | ||
| Min | 34 | 28 | ||
| Max | 72 | 76 | ||
| Gender | Female | 8 (36.4%) | 5 (35.7%) | 0.968 |
| Male | 14 (63.6%) | 9 (64.3%) | ||
| Smoking history | Current/Former | 18 (81.8%) | 12 (85.7%) | 1.000 |
| Never | 3 (13.6%) | 2 (14.3%) | ||
| Unknown | 1 (4.6%) | 0 (0.0%) | ||
| EGFR mutation status | Mutant | 17 (77.3%) | 0 (0.0%) | <0.0001 |
| Wild type | 5 (22.7%) | 14 (100.0%) | ||
| Human papillomavirus (HPV) status | Positive | 5 (22.7%) | 5 (35.7%) | 0.396 |
| Negative | 17 (77.3%) | 9 (64.3%) | ||
| Low-risk HPV subtype status | Positive | 4 (18.2%) | 0 (0.0%) | 0.118 |
| Negative | 18 (81.8%) | 13 (92.9%) | ||
| Unknown | 0 (0.0%) | 1 (7.1%) | ||
| High-risk HPV subtype status | Positive | 1 (4.5%) | 4 (28.6%) | 0.024 |
| Negative | 21 (95.5%) | 9 (64.3%) | ||
| Unknown | 0 (0.0%) | 1 (7.1%) |
Statistically significant P-value in bold.