Table 1.

Analysis of data from the International epidemiology Databases to Evaluate AIDS (IeDEA) to inform WHO guidelines

Guideline	Evidence contributed	Analyses performed
WHO 2010 ART guidelines for HIV infection in infants and children	Definition of immunological failure in children on ART	Risk of mortality associated with different ages and CD4 values in children on ART [11]
WHO 2013 Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection	Support for ART for all children aged <5 years irrespective of disease severity	Causal modelling of observational data comparing mortality with immediate versus deferred ART in children aged 1–5 years [12]
WHO 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection	Support for ART for all children aged <15 years irrespective of disease severity	Causal modelling of observational data comparing mortality and growth with immediate versus deferred ART in children aged 1–15 [13]
WHO 2017 guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy	Definition of burden of advanced HIV disease in adults and children	Proportion of adults in IeDEA and COHERE collaborations presenting with advanced HIV disease; proportion of children aged<5 years in IeDEA-SA presenting with advanced HIV disease [14,15]