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. Author manuscript; available in PMC: 2019 Sep 14.
Published in final edited form as: Circ Res. 2018 Sep 14;123(7):849–867. doi: 10.1161/CIRCRESAHA.118.311378

Figure 4: Conceptual model for the pathogenic role of cellular senescence in vascular aging.

Figure 4:

The model predicts that increased presence of senescent endothelial and/or smooth muscle cell (SMC) in the aged vasculature and their proinflammatory secretome (SASP: senescence-associated secretory phenotype) contributes to impaired angiogenesis and microvascular rarefaction, pathological remodeling of the ECM, barrier disruption, chronic inflammation and atherogenesis.