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. Author manuscript; available in PMC: 2019 Nov 12.
Published in final edited form as: Cancer Cell. 2018 Oct 25;34(5):792–806.e5. doi: 10.1016/j.ccell.2018.09.010

Figure 5. G660D HER2 activation involves asymmetric dimerization of the KD.

Figure 5.

(A) Active HER2 asymmetric dimer model. Residues involved in the asymmetric kinase domain interactions in HER2 deduced from EGFR structural studies are shown (inset). (B) IL-3 independent cell survival of BaF3 cells stably expressing the indicated kinase, activator or receiver mutants. Data are presented as mean ± Standard Deviation (SD) of relative cell survival of twelve replicates and representative of three independent experiments. (C) Cartoon representation of the proposed mechanism of activation of HER2 G660D. The number shown below corresponds to the lane number in (B). See also Figure S3.