Fig 6. KF results as the prior mean and standard deviation are varied for N = 3 replicates simulated at (a) low (b) medium and (c) high noise levels under log-normal noise model.
The horizontal axis represents an increase in the prior standard deviation, σm,0. The vertical axis represents the offset, μoffset, which was added to the ground truth log reactivity to define the prior mean. The value of each bin is the RMS error calculated over all nucleotides in our database between the ground truth and Kalman filtered reactivities. Error calculations were carried out in the log domain and the ground truth values were the log reactivities. See Methods for RMS calculation details.