Fig 8. Kalman filtering results using an accurate (unbiased) prior performs comparable to log-averaging when the uncertainty is increased.

RMS errors were calculated over all nucleotides in our database. Error calculations were carried out in the log domain and the ground truth values were the log reactivity. See Methods for RMS calculation details. The prior mean was fixed to the ideal value. Its standard deviation, σ_m,0, was then increased. As the standard deviation increased, the more comparable the Kalman filtering’s performance was to log-averaging.