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. 2018 Nov 9;14(11):e1007779. doi: 10.1371/journal.pgen.1007779

Fig 5. Association of KRAS p.G12D driver mutation with mutational signature 4 and with pack years smoked by people with lung adenocarcinoma.

Fig 5

(A) Proportion of mutations attributable to signature 4 in lung adenocarcinoma (LUAD) tumours that are wild-type and mutant for KRAS p.G12D. (B) Number of pack years smoked by people with LUAD who have a previous history of smoking, in tumours that are wild-type and mutant for KRAS p.G12D. Box plots show median and quartiles, with significance by two-sided Mann Whitney U-Test in (A) and unpaired t-test in (B). * denotes P < 0.05.