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Values of Ki for Inhibition of HIV-1 Protease
| R | Ki (pM) | Relative Affinitya | Ref. | |
|---|---|---|---|---|
 darunavir |
10 ± 1 | — | 9 | |
 |
14 | 1.0 | 1b | |
 |
12 | 1.2 | 1b | |
 |
12.7 | 1.3 | 10 | |
 |
10 | 1.6 | 11 | |
 |
8.9 | 1.8 | 10 | |
 1 |
0.5 ± 0.3 | 20 | This work |
Values of Ki can depend on assay conditions. Here, values are compared by using darunavir as a benchmark with Relative Affinity = Ki,darunavir /Ki,analog as reported in the indicated reference.
