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. Author manuscript; available in PMC: 2019 Aug 13.
Published in final edited form as: Biomacromolecules. 2018 Jul 23;19(8):3361–3370. doi: 10.1021/acs.biomac.8b00640

Figure 4. Filamentous PP2 micelle (fVPM) characterization.

Figure 4.

Filamentous micelles with aspect ratio of 20 were formulated with PP2 polymer and shown to have lower cellular uptake by macrophages than spherical micelle. (A) TEM image of fVPM (inset: sVPM for comparison, scale bar = 100 nm), (B) aspect ratio (AR) distribution of fVPM post-lyophilization reconstituted in water, (C) DLS mean size and PDI of fVPM following reconstitution with 1x PBS (n=3, mean ± SD), and (D) sVPM and fVPM uptake efficiency in RAW 264.7 cells and geometric mean of uptake normalized to untreated cells measured by flow cytometry after treatment for 1 hr at equivalent VP concentrations (n=4, mean ± SD, One-way ANOVA with Tukey post-hoc test).