. Author manuscript; available in PMC: 2019 Nov 21.

Published in final edited form as: J Med Chem. 2018 Oct 31;61(22):10206–10217. doi: 10.1021/acs.jmedchem.8b01363

Table 2.

Structure and activity of a series of MBP derivatives.

Number	IC₅₀ (nM)	pIC₅₀	Phenol pK _a^a
1	43 ±9 nM	7.4	9.7
3	68 ± 11 nM	7.2	9.6
5	7500 ± 1200 nM	5.1	7.0
7	6400 ± 900 nM	5.2	9.8; 14.3
17	17 ± 3 nM	7.8	11.2
18	430 ± 20 nM	6.4	9.2
19	1600 ± 400 nM	5.8	7.5

Calculated pK_a values³³