. Author manuscript; available in PMC: 2019 Nov 21.

Published in final edited form as: J Med Chem. 2018 Oct 31;61(22):10206–10217. doi: 10.1021/acs.jmedchem.8b01363

Table 3.

Structure and activity of MBP inhibitor molecules.

Number	IC₅₀ (nM)	pIC₅₀	Number	IC₅₀ (nM)	pIC₅₀	Number	IC₅₀ (nM)	pIC₅₀
20	3900 ± 900 nM	5.4	25	3800 ± 1100 nM	5.4	30	1200 ± 400 nM	5.9
21	85 ± 17 nM	7.1	26	>50000 nM	0 4.3	31	1700 ± 400 nM	5.8
22	420 ± 60 nM	6.4	27	37 ± 8 nM	7.4	32	11 ± 1.8 nM	8.0
23	∼200000 nM	< 3.7	28	∼19000 nM	4.7	33	8.0 ± 1.1 nM	8.1
24	2700 ± 600 nM	5.6	29	540 ± 80 nM	6.3	33	8.0 ± 1.1 nM	8.1