Table 4.
Single concentration cross-inhibition studies of MBPs against PAN endonuclease and three other dinuclear metalloenzymes. Final inhibitor concentration employed in assays is indicated in the table header for each enzyme. Percent inhibition is listed and colored from yellow to red with increasing inhibition values.
Compound | PAN Endonuclease (500 nM) | Human Arginase 1 (200 μM) | Human MetAP1 Mn2+isoform (200 μM) | NDM-1 (200 μM) |
---|---|---|---|---|
1 | 96 | 8 | 27 | 12 |
2 | 21 | 5 | 6 | 15 |
3 | 94 | 1 | 5 | 4 |
5 | 9 | 2 | 9 | 25 |
7 | 15 | 82 | 4 | 15 |
8 | 18 | 41 | 6 | 6 |
14 | 67 | 22 | 27 | 10 |
15 | 5 | 16 | 16 | 87 |
17 | 97 | 24 | 0 | 6 |
18 | 44 | 8 | 64 | 9 |
19 | 28 | 0 | 0 | 3 |
20 | 21 | 2 | 1 | 1 |
21 | 81 | 12 | 32 | 22 |
22 | 46 | 9 | 34 | 84 |
23 | 0 | 11 | 0 | 7 |
24 | 30 | 5 | 35 | 8 |
25 | 22 | 8 | 24 | 6 |
26 | 7 | 5 | 3 | 8 |
27 | 96 | 7 | 1 | 99 |
28 | 15 | 83 | 2 | 43 |
29 | 88 | 0 | 33 | 8 |
30 | 30 | 6 | 4 | 3 |
31 | 21 | 49 | 37 | 63 |
32 | 95 | 92 | 58 | 92 |
33 | 98 | 32 | 30 | 61 |