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. Author manuscript; available in PMC: 2019 Nov 21.
Published in final edited form as: J Med Chem. 2018 Oct 31;61(22):10206–10217. doi: 10.1021/acs.jmedchem.8b01363

Table 4.

Single concentration cross-inhibition studies of MBPs against PAN endonuclease and three other dinuclear metalloenzymes. Final inhibitor concentration employed in assays is indicated in the table header for each enzyme. Percent inhibition is listed and colored from yellow to red with increasing inhibition values.

Compound PAN Endonuclease (500 nM) Human Arginase 1 (200 μM) Human MetAP1 Mn2+isoform (200 μM) NDM-1 (200 μM)
1 96 8 27 12
2 21 5 6 15
3 94 1 5 4
5 9 2 9 25
7 15 82 4 15
8 18 41 6 6
14 67 22 27 10
15 5 16 16 87
17 97 24 0 6
18 44 8 64 9
19 28 0 0 3
20 21 2 1 1
21 81 12 32 22
22 46 9 34 84
23 0 11 0 7
24 30 5 35 8
25 22 8 24 6
26 7 5 3 8
27 96 7 1 99
28 15 83 2 43
29 88 0 33 8
30 30 6 4 3
31 21 49 37 63
32 95 92 58 92
33 98 32 30 61