Table 2.

Tissue weights of PAPP-A KO mice

	% of WT
	Males	Females
Pericardial fat	40 ± 6**	51 ± 10**
Inguinal fat	84 ± 6	101 ± 7
Mesenteric fat	87 ± 7	73 ± 7
Liver	106 ± 9	105 ± 7
Heart	106 ± 6	111 ± 2*
Skeletal muscle	111 ± 5	109 ± 6

PAPP-A KO and WT litter-mates were fed a HFD for 20 weeks. Tissue weights were divided by body weight prior to the start of HFD to take into account the smaller size of PAPP-A KO mice compared to WT littermates [20] and females compared to males. These values were expressed as % of WT (set as 100%). Results are mean ± SEM of N = 7–10 mice.

^*P < 0.05;

^**P = 0.0002