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. Author manuscript; available in PMC: 2019 Nov 21.
Published in final edited form as: J Med Chem. 2018 Nov 8;61(22):10299–10309. doi: 10.1021/acs.jmedchem.8b01487

Figure 4.

Figure 4.

Stereoview of the Polder omit map of RTS-V5 bound to monomer A of HDAC6 (contoured at 3.0 σ) (PDB ID 6CW8). Atoms are color-coded as follows: C = orange (RTS-V5) or light blue (protein), N = blue, O = red, Zn2+ = gray sphere, solvent = red spheres. Metal coordination and hydrogen bond interactions are indicated by solid and dashed black lines, respectively. The Zn2+ coordination geometry is pentacoordinate square pyramidal.