(A) Adipose weight, (B) body weight (C), serum cholesterol, (D) triacylglycerols, (E) HDL, (F) LDL, and (G) VLDL concentrations, and (H) histopathology observations in female and male WT mice compared to female and male Cyp2b-KD mice at 35-weeks of age show minor periportal hypertrophy in Cyp2b-KD mice. Significant differences between WT and Cyp2b-KD mice were assessed by Student’s t-test (n = 9–11). An asterisk indicates a significant difference with a p < 0.05, two asterisks indicate a p < 0.01, and three asterisks indicate a p < 0.001. WT = wild-type mice, KD = Cyp2b-KD mice, M = male, F= female.