Table 3.

Results of longitudinal mixed effects models for memory, verbal fluency, and Mini-Mental State Examination (MMSE) number of errors

	Word List Delayed Recall		Animal Fluency		MMSE*
Variables	β (SE)	p-value	β (SE)	p-value	β (SE)	p-value
Time (Age centered at 85)	0.01	0.91	0.17	0.49	0.001	0.97
Braak III/IV vs 0/I/II × time	−0.01	0.82	0.09	0.42	−0.01	0.42
Braak V/VI vs 0/I/II × time	−0.07	0.26	−0.23	0.07	0.03	0.03*
Neuritic plaques (moderate /frequent vs none/sparse) × time	−0.08	0.10	−0.12	0.20	0.02	0.04*
Gross infarcts (present vs absent) × time	−0.06	0.22	−0.24	0.008*	0.05	<0.0001*
Lewy body (present vs absent) × time	0.07	0.26	−0.05	0.64	0.01	0.28
Hippocampal sclerosis (present vs absent) × time	−0.13	0.15	−0.28	0.11	0.06	0.003*
APOE ε4 allele (present vs absent) × time	−0.16	0.006*	−0.01	0.92	0.03	0.02*

Analyses were adjusted for education, education*time, pathology main effects and age at death

^*Poisson model using errors in MMSE test scores as the outcomes (i.e. positive slope implies an increase in rate of errors on the MMSE and a decline in scores on the MMSE).