Table 3a.
Clinical outcomes among pediatric kidney transplant patients subdivided by presence of dnDSA and clinical stability at the time of dnDSA detection. Results are adjusted for age at transplant, type of transplant donor, incidence of delayed graft function, cold ischemia time, and baseline estimated glomerular filtration rate.
| Outcome | No
dnDSA n=70 |
dnDSA detected on
screening n=20 |
dnDSA detected on for-cause
testing n=13 |
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|---|---|---|---|---|---|---|---|---|
|
|
|
|
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| aHR | aHR (95%CI) | p | aHR (95%CI) | p | ||||
| eGFR 30% decline | Ref | 0.88 (0.30–2.00) | 0.598 | 2.80 (1.08–7.27) | 0.034 | |||
| Graft loss | Ref | 1.75 (0.28–10.73) | 0.546 | 7.34 (1.37–39.23) | 0.020 | |||
| Mean | SD | Mean | SD | p | Mean | SD | p | |
| eGFR at 3 years (ml/min/1.73m2) | 75.34 | 23.65 | 74.26 | 36.20 | 0.632 | 60.84 | 30.31 | 0.054 |
| n=244.7 person-years | n=41.8 person-years | n=22.5 person-years | ||||||
|
|
|
|
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| IR | RR | IR | aHR (95% CI) | p | IR | aHR (95% CI) | p | |
| Rejection (at 3 years) | 0.15 | Ref | 0.36 | 2.41 (1.27–4.54) | 0.007 | 0.71 | 2.43 (1.00–5.90) | 0.050 |