Table 4.
Risk of 30% decline in estimated glomerular filtration rate among pediatric kidney transplant patients, comparing patients with dnDSA detected by screening to patients who did not develop dnDSA within 2 years of kidney transplant, using different MFI thresholds to adjudicate DSA positivity. Results are adjusted for age at transplant, type of transplant donor, delayed graft function, cold ischemia time, and baseline estimated glomerular filtration rate.
| No dnDSA |
dnDSA detected on screening | 30% decline in renal function: No dnDSA vs dnDSA detected on screening | ||
|---|---|---|---|---|
|
|
|
|
||
| n1 | n1 | aHR (95%CI) | p | |
| Any MFI | 70 | 20 | 0.88 (0.30–2.00) | 0.598 |
| MFI ≥1000 | 72 | 17 | 1.01 (0.38–2.69) | 0.976 |
| MFI ≥1500 | 75 | 17 | 0.97 (0.33–2.85) | 0.955 |
| MFI ≥2500 | 79 | 17 | 1.04 (0.39–2.76) | 0.938 |
| MFI ≥8000 | 90 | 9 | 0.99 (0.23–4.29) | 0.994 |
1
Total number of patients does not consistently equal 90 due to some patients being reclassified as ‘dnDSA on for-cause testing’ at each threshhold