Table 4.

Multivariate Analyses of Mean Differences in Domains of Quality of Life Based on Self-Reported Cognitive Complaints, Diagnosis, and Cognitive Impairment (n=259)

Outcome	R2	F	Cognitive Difficultiesa	MCIb	ADb	MMSE
EQ-5D	0.04	2.33	−.05**	−0.02	−0.01	−0.004
QOL-AD	0.07	5.02***	−2.24***	−1.87*	−2.16*	−0.12
DEM-QOL	0.24	19.57***	−7.26***	−6.42***	−5.42**	−0.09
GDSc	0.14	10.61***	2.17***	3.16***	1.54	0.13
BAI	0.13	9.54***	3.89***	1.15	1.10	0.02
PSS	0.19	14.87***	4.66***	2.31**	1.46	0.03
SF-12 MCS	0.10	7.02***	−2.43**	−3.48***	−1.18	0.20
IADL Scaled	0.15	11.34***	0.14**	0.07	0.21*	−0.03**
SF-12 PCS	0.05	3.34**	−3.37**	1.28	2.34	−0.30
			Cognitive Symptom Distresse	MCIb	ADb	MMSE
EQ-5D	0.02	1.36	−0.03	−0.02	−0.01	−0.003
EQ-VAS	0.02	1.20	3.80	−0.29	1.48	−0.10
QOL-AD	0.11	7.93***	−3.10***	−1.62*	−2.20*	−0.10
DEM-QOL	0.26	22.65***	−8.08***	−5.89***	−5.51**	−0.03
GDSc	0.14	11.07***	2.31***	3.01***	1.56	0.11
BAI	0.09	6.61***	3.26***	1.04	1.12	−0.02
PSS	0.21	16.87***	5.04***	2.00*	1.51	0.02
SF-12 MCS	0.12	8.39***	−3.09***	−3.24**	−1.22	0.22
IADL Scaled	0.15	11.06***	0.13*	0.06	0.21*	−0.04**
SF-12 PCS	0.04	2.50*	−2.55*	1.34	2.32	−0.27
			More Memory Problems than Mostf	MCIb	ADb	MMSE
QOL-AD	0.07	4.73***	−2.61***	−1.02	−1.13	−0.05
DEM-QOL	0.17	13.14***	−6.34***	4.54**	3.05	0.07
GDSc	0.21	17.04***	3.98***	1.73*	0.06	0.05
BAI	0.05	3.29**	2.53**	0.51	0.21	0.06
PSS	0.09	6.54***	3.34***	1.40	0.05	−0.07
SF-12 MCS	0.14	9.89***	−4.35***	−1.92	0.49	0.29

Note. AD = Alzheimer’s Disease, BADL = Basic Activities of Daily Living, BAI = Beck Anxiety Inventory, EQ= Euro-QOL, GDS = Geriatric Depression Scale, MCI = Mild Cognitive Impairment, IADL=Instrumental Activities of Daily Living, MCI = Mild Cognitive Impairment, MCS = Mental Composite Scale, MMSE = Mini Mental Status Exam, PCS = Physical Composite Scale, PPS = Perceived Stress Scale, QOL = Quality of Life, SF-12 = Short Form Health Survey, VAS = Visual Analog Scale.

^aEndorsed greater cognitive difficulties than most individuals who were known to have normal cognition (Cognitive Difficulties Scale (CDS); cut point ≥ 72 score).

^bReference is cognitively normal (CN) group.

^cLog link back transformed.

^dEntered as binary variable. The cut point separated one-third of the sample into the high group.

^eEndorsed greater distress from cognitive difficulties than most individuals who were known to have normal cognition (General Distress Index (GDI); cut point ≥18 score).

^fSingle “yes” or “no” item from Geriatric Depression Scale (GDS).

^*<.05

^**≤.01

^***≤.001