Table 1.
Demographics and Social Status at Entry
| BAP + (n=45) |
BAP − (n=374) |
p | Adjusted p | Adjusted effect size (95%CI) | |
|---|---|---|---|---|---|
| Demographics | |||||
| Age, mean years (SD) | 67.9 (14.6) | 65.7 (9.7) | 0.4 a | - | - |
| Followup duration, mean months (SD) | 119.9 (78.8) | 121.9 (78.7) | 0.87 a | - | - |
| Men, % | 48.90% | 24.30% | <0.001b | - | - |
| Education, mean years (SD) | 16.4 (2.3) | 16.3 (2.5) | 0.79 a | - | - |
| White, % | 82.20% | 83.90% | 0.77 b | - | - |
| Righthanders, % | 86.70% | 88.80% | 0.68 b | - | - |
| APOE e4 carrier, % | 48.80% | 44.00% | 0.55 b | - | - |
| Autism Spectrum Quotient, mean (SD) | |||||
| % Social Skills | 22.0 (6.4) | 12.2 (9.9) | <0.001 a | <0.001 c | 9.36 (6.27, 12.44) † |
| % Attention Switching | 22.2 (6.1) | 23.4 (11.6) | 0.52 a | 0.5 c | −1.23 (−4.82, 2.36) † |
| % Attention to Detail | 21.7 (7.7) | 32.1 (16.6) | <0.001 a | <0.001 c | −9.46 (−14.53, −4.39) † |
| % Communication | 17.1 (4.9) | 11.8 (9.7) | <0.001 a | <0.001 c | 5.31 (2.30, 8.31) † |
| % Ideas | 16.9 (6.8) | 20.5 (11.5) | 0.047 a | 0.03 c | −3.97 (−7.51, −0.43) † |
| Subjective Cognitive Impairment | |||||
| MANS-self, mean (SD) | 29.7 (36.6) | 12.6 (24.1) | <0.0001a | <0.0001 c | 16.25 (8.19, 24.31) † |
| MANS-self score > 0, % | 57.80% | 45.30% | 0.11 b | 0.096 d | 1.74 (0.91, 3.32) * |
| MANS informant, mean (SD) | 23.1 (35.5) | 7.0 (18.6) | <0.0001a | <0.0001 c | 14.31 (7.29, 21.33) † |
| MANS informant score > 0, % | 48.60% | 27.50% | <0.01 b | 0.02 d | 2.31 (1.14, 4.68) * |
| Social Status | |||||
| Married currently, % | 62.20% | 74.30% | 0.08 b | 0.05 d | 0.51 (0.26, 1.00) * |
| Multiple divorces, % | 24.40% | 11.30% | 0.01 b | 0.02 d | 2.60 (1.20, 5.63) * |
| Number of children, mean (SD) | 1.9 (1.6) | 1.7 (1.3) | 0.4 a | 0.49 c | 0.14 (−0.27, 0.55) † |
| With biological children, % | 68.90% | 76.30% | 0.28 b | 0.23 d | 0.64 (0.32, 1.31) * |
| zip code median income, mean (SD) | $59,892 ($24,850) | $59,901 ($25,675) | 0.99 a | 0.76 c | $−1,281.40 ($−9,696.78, $7,133.98) † |
| Occupation SVP, mean (SD) | 6.9 (1.4) | 6.9 (1.3) | 0.99 a | 0.41 c | −0.15 (−0.52, 0.21) † |
| Occupation GED, mean (SD) | 12.8 (2.6) | 12.9 (2.4) | 0.87 a | 0.45 c | −0.26 (−0.93, 0.41) † |
Demographic and social status results reflect data gathered from the visit of the patients’ first Autism Spectrum Quotient screening.
BAP = Broad Autism Phenotype; SD = standard deviation; MANS = Multidimensional Assessment of Neurodegenerative Symptoms; SVP = Specific Vocational Preparation; GED = General Educational Development; CI = confidence interval;
a
T-test;
b
Chi-squared test;
c
Linear regression model adjusted for age, sex, and education;
d
Logistic regression model adjusted for age, sex, and education;
*
Odds ratio of BAP+ vs BAP− adjusted for age, sex, and education;
†
Least squares mean difference between BAP+ and BAP− adjusted for age, sex, and education (BAP+ minus BAP−)