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Region of interest analyses in the medial frontal cortex and associations with pain sensitivity and RA disease activity. A) The pressure required for the high intensity metacarpophalangeal (MCP) joint stimulus negatively correlated with resting regional cerebral blood flow (rCBF). B) The pain evoked by the low intensity metacarpophalangeal MCP stimulus positively correlated with resting rCBF. C) Disease Activity Score in 28 Joints (DAS28) positively correlated with resting rCBF.
