Table 2.
Association of an overall polygenic risk score with melanoma risk in the Australia and Leeds studies
| Overall Polygenic Risk Score |
Australia |
Leeds |
||||||
|---|---|---|---|---|---|---|---|---|
| Range | Case Individuals, n (%) |
Control Individuals, n (%) |
Odds Ratio1 (95% CI) |
Range | Case Individuals, n (%) |
Control Individuals, n (%) |
Odds Ratio1 (95% CI) |
|
| Tertiles | ||||||||
| 1 | –2.11 to 0.16 | 103 (18) | 152 (33) | 1.00 | –1.46 to 0.16 | 160 (17) | 163 (33) | 1.00 |
| 2 | 0.16 to 0.60 | 158 (27) | 170 (37) | 1.38 (0.97–1.94) | 0.16 to 0.60 | 312 (32) | 154 (31) | 2.09 (1.56–2.82) |
| 3 | 0.60 to 2.52 | 317 (55) | 135 (30) | 3.22 (2.30–4.51) | 0.60 to 2.69 | 492 (51) | 179 (36) | 2.84 (2.14–3.77) |
| P trend | <0.0001 | <0.0001 | ||||||
| P int2 | 0.29 | |||||||
| Deciles | ||||||||
| 1 | –2.11 to –0.26 | 24 (4) | 43 (9) | 1.00 | –1.46 to –0.27 | 48 (5) | 53 (11) | 1.00 |
| 2 | –0.26 to –0.05 | 23 (4) | 45 (10) | 0.93 (0.45–1.94) | –0.26 to –0.05 | 38 (4) | 50 (10) | 0.88 (0.49–1.58) |
| 3 | –0.05 to 0.13 | 37 (6) | 43 (9) | 1.47 (0.73–2.94) | –0.05 to 0.13 | 64 (7) | 52 (10) | 1.45 (0.84–2.50) |
| 4 | 0.13 to 0.27 | 51 (9) | 54 (12) | 1.83 (0.95–3.54) | 0.13 to 0.27 | 83 (9) | 42 (8) | 2.36 (1.36–4.10) |
| 5 | 0.28 to 0.37 | 54 (9) | 76 (17) | 1.23 (0.65–2.32) | 0.27 to 0.37 | 57 (6) | 41 (8) | 1.61 (0.91–2.84) |
| 6 | 0.37 to 0.49 | 41 (7) | 30 (7) | 2.51 (1.23–5.13) | 0.37 to 0.49 | 109 (11) | 43 (9) | 2.99 (1.75–5.10) |
| 7 | 0.49 to 0.63 | 49 (8) | 41 (9) | 2.13 (1.08–4.18) | 0.49 to 0.63 | 91 (9) | 55 (11) | 1.94 (1.14–3.27) |
| 8 | 0.64 to 0.82 | 77 (13) | 44 (10) | 3.06 (1.60–5.83) | 0.64 to 0.83 | 106 (11) | 51 (10) | 2.44 (1.45–4.12) |
| 9 | 0.83 to 1.06 | 73 (13) | 38 (8) | 3.03 (1.56–5.88) | 0.83 to 1.06 | 118 (12) | 57 (11) | 2.44 (1.46–4.08) |
| 10 | 1.06 to 2.52 | 149 (26) | 43 (9) | 5.88 (3.14–11.03) | 1.06 to 2.69 | 250 (26) | 52 (10) | 5.62 (3.41–9.29) |
| P trend | <0.0001 | <0.0001 | ||||||
| P int2 | 0.28 | |||||||
| OPERA3 | 1.75 (1.53–2.01) | 1.63 (1.46–1.83) | ||||||
| P int2 | 0.40 | |||||||
1
Models are adjusted for demographic and study design factors of age, sex, city of recruitment, and European ancestry.
2
P-value for interaction comparing trends across countries.
3
Odds ratio per adjusted standard deviation, stratified by location (Australia/Leeds) and adjusted for age and sex, using the OPERA method (Hopper, 2015).