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. 2018 Nov 21;9(12):1156. doi: 10.1038/s41419-018-1191-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Percentages of total Caspase-3-activated naive CD19⁺CD27⁻ (white circles) and memory CD19⁺CD27⁺ (light gray circles) unstimulated B cells from healthy controls (a). Percentages of viable, early-apoptotic, intermediate-apoptotic, and late-apoptotic/necrotic cells detected in previously gated naive CD19⁺CD27^– (white circles) and memory CD19⁺CD27⁺ (light gray circles) unstimulated B cells from healthy controls (b). Percentages of total Caspase-3-activated naive CD19⁺CD27^– (c) and memory CD19⁺CD27⁺ (e) unstimulated B cells from healthy controls (white circles), CVID (light gray circles) and apoptosis-prone CVID (dark gray circles) patients. Percentages of viable, early-apoptotic, intermediate-apoptotic, and late-apoptotic/necrotic cells detected in previously gated naive CD19⁺CD27^– (d) and memory CD19⁺CD27⁺ (f) unstimulated B cells from healthy controls (white circles), CVID (light gray circles), and apoptosis-prone CVID (dark gray circles) patients. Data are given as medians (Mann–Whitney and Kruskal–Wallis test P values: *P < 0.05; **P < 0.01; ***P < 0.001). HC healthy controls (n = 9), CVID common variable immunodeficiency patients (n = 5), AP-CVID apoptosis-prone CVID patients (n = 4)