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. 2018 Nov 21;9:4910. doi: 10.1038/s41467-018-07463-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Comparative analyses of stomach development and gastric cancer. a Two-tailed hypergeometric tests were conducted to determine whether there is a significant overlap of altered genes on a specific pathway between stomach development and diffuse-type gastric cancer. Upper left: Correlations on eight signaling pathways between stomach development and DGC. Upper right: the number of significantly altered and overlapping genes on eight signaling pathways in stomach development and DGC. b Venn diagram of genes or proteins (ANOVA, FDR < 0.01) differentially expressed in stomach development and DGC (ttest, FDR < 0.05, ratio of tumor over nearby tissues ≥ 2) (Lower left); Temporal expression patterns of 939 overlapping genes across 15 timepoints (Lower right). Right panel, horizontal color bars: red, Ph1; blue, Ph2; and orange, Ph3. Vertical color bars: deep pink, group 1; gold, group 2; purple, group 3; and cyan, group 4