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. 2018 Nov 21;8:17210. doi: 10.1038/s41598-018-35496-z

Figure 2.

Figure 2

FGF19-M52 analogue protects Abcb4−/− mice from age-related liver damage and HCC progression. qPCR of hepatic (a) Cyp7a1 (b) Cyp8b1. Expression was normalized to Cyclophillin. (c) BA composition (CA/MCA Ratio) in murine plasma and liver. (d) Macroscopic appearance of livers, normalized tumor number and maximum tumor size of 16-months-old Abcb4−/− mice (n = 14–24). (e) Biochemical parameters of liver damage in 16 months old Abcb4−/− mice. Statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001) was assessed by Mann-Whitney’s U test.