Table 2.
Liver Bile Acid Composition.
| Genotype | CA% | UDCA% | CDCA% | DCA% | LCA% | MCA% | TCA% | TUDCA% | TCDCA% | TDCA% | TLCA% | TMCA% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abcb4−/−-GFP | 1.23 ± 0.27 | 0.36 ± 0.03 | 0.5 ± 0.09 | 0.01 ± 0.01 | 0.02 ± 0 | 34.73 ± 3.77 | 21.31 ± 1.69 | 0.88 ± 0.27 | 2.99 ± 0.25 | 0.18 ± 0.05 | 0.05 ± 0.02 | 37.74 ± 5.06 |
| Abcb4−/−-M52 | 0.7 ± 0.45 | 0.82 ± 0.15 | 0.96 ± 0.11 | 0 ± 0 | 0.06 ± 0.02 | 70.04 ± 4.6 | 4.02 ± 1.86 | 0.19 ± 0.05 | 2.15 ± 0.26 | 0.04 ± 0.04 | 0 ± 0 | 21.02 ± 3.82 |
| Fxr−/−-GFP | 5.31 ± 0.24 | 1.15 ± 0.25 | 0.78 ± 0.18 | 0.56 ± 0.12 | 0.12 ± 0.03 | 25.98 ± 1.61 | 52.59 ± 2.88 | 0.23 ± 0.08 | 1.57 ± 0.34 | 8.62 ± 1.54 | 0.27 ± 0.09 | 2.83 ± 0.42 |
| Fxr−/−-M52 | 1.28 ± 0.24 | 0.17 ± 0.04 | 0.14 ± 0.02 | 0.07 ± 0.02 | 0.02 ± 0 | 16.02 ± 3.9 | 24.96 ± 4.79 | 0.68 ± 0.1 | 0.3 ± 0.04 | 0.82 ± 0.22 | 0.05 ± 0.01 | 55.5 ± 4.09 |
CA, cholic acid; UDCA, ursodeoxycholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; LCA, lithocholic acid; MCA, muricholic acids; TCA, taurocholic acid; TUDCA, tauroursodeoxycholic acid; TCDCA, taurinechenodeoxycholic acid; TDCA, taurinedeoxycholic acid; TLCA, taurinelithocholic acid; TMCA, taurinemuricholic acids.