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. 2018 Nov 21;8:17156. doi: 10.1038/s41598-018-35218-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of calorie intake on the chronological stage of zebrafish beta-cells. (a) The impact of calorie intake on the classification stage of beta-cells was investigated. A higher proportion of beta-cells from the animals fed three-times-a-day were classified by GERAS as ‘Adult’, as compared to cells from animals on intermittent feeding, in which a majority of the cells (65%) were classified as adolescent. (Fisher’s Exact Test, **p-value < 0.01). (b) Volcano plot summarizing the differential expression analysis of beta-cells classified as ‘Adult’ or ‘Adolescent’ from the animals fed three-times a day. Colored dots represent significantly regulated genes (false-discovery rate (fdr) < 0.05). Red dots represent up-regulated genes, while blue dots represent down-regulated genes. (c) Gene-ontology (GO) analysis of the differentially regulated genes using DAVID⁴². This analysis includes the down-regulated (blue in b) and up-regulated (red in b) genes. Zebrafish illustration provided with permission from Priyanka Oberoi.