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. 2018 Nov 21;8:17156. doi: 10.1038/s41598-018-35218-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of junba reduces the proliferation of zebrafish beta-cells. (a) Maximum intensity confocal projections of beta-cells from a 30 dpf animal showing mosaic expression of nls-BFP-2A-DN-junba (blue) together with Tg(ins:FUCCI-S/G2/M) (green) and Tg(ins:FUCCI-G0/G1) (red). Arrowheads mark proliferating beta-cells, as indicated by the presence of green fluorescence and absence of red fluorescence. Scale bar 10 μm. (b) Tukey-style boxplots showing the percentage of proliferating beta-cells among BFP+ and BFP- cells. BFP+ cells co-express DN-junba, while the BFP- cells act as internal control. The BFP+ cells show a significant decrease in the proportion of proliferating cells (t-test, **p-value < 0.01). ‘n’ denotes number of islets.