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. 2018 Nov 21;9:4919. doi: 10.1038/s41467-018-07276-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Performance of SAMC. p-values from 10,000 permutations, compared to SAMC p-values with t₀ = 1,000 and 1,000,000 permutations (in log scale). Evaluated on 7989 methylation sites on chromosome 22, from the KORA dataset. Sites with $ĥ^{2} = 0$ (3,779 sites), omitted for clarity of presentation, showing a total of 4210 sites, with 99.95% CIs shown. SAMC is well calibrated