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. 2018 Nov 21;9:4904. doi: 10.1038/s41467-018-07334-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Tissue Immunofluorescence imaging of total EGFR and phosphorylated-EGFR (p-EGFR) in brain and flank tumors. a Images showing total EGFR in brain and flank tumors (red) overlaid with Hoechst (blue), treated with placebo, low (33 mg kg⁻¹) and high (100 mg kg⁻¹) dose erlotinib, and graphs (on right) showing quantitative analysis EGFR levels over whole tumor region in each treatment group. b Images showing p-EGFR in brain and flank tumors (red) overlaid with Hoechst (blue), with placebo, low (33 mg kg⁻¹) and high (100 mg kg⁻¹) dose erlotinib and graphs (on right) showing average (mean) intensity of p- EGFR levels in each treatment group. (scalebars on images represent 250 µm, error bars represent 1 standard deviation, n = 2 for brain, n = 3 for flank)