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. 2018 Nov 21;8:17171. doi: 10.1038/s41598-018-35649-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Age differences in integrated PFC-evoked inhibition of BLA neuron firing. A portion of BLA neurons were categorized as Inhibited by single pulse stimulation of PFC in PND 72–75 and PND 39 rats. (A) Shown here is an example of a BLA neuron from a PND 39 rat (left) and PND 72–75 rat (right) that fit criteria for Inhibition response type. Fifty consecutive overlaid traces are shown here of the response to the same stimulation intensity. Stimulation occurs at the arrowhead. Stimulation artifacts were blanked for clarity. (B) The response to PFC stimulation was quantified from Inhibited neurons as the Area Under the peristimulus time histogram Curve (AUC). (C) There was weaker inhibition evoked by PFC stimulation in the LAT of PND 39 rats compared to PND 72–75 rats (PrL → LAT, IL → LAT, *p < 0.05, two-way ANOVA for both comparisons). (D) Similarly, in the BA there was significantly less inhibition in PND 39 PrL → BA and IL → BA compared to PND 72–75 (*p < 0.05, two-way ANOVA for both comparisons). (E) The duration of inhibition was quantified and found to be significantly greater in PND 72–75 rats compared to PND 39 rats for IL → LAT responses (*p < 0.05, post-hoc Holm-Sidak’s multiple comparisons test after two-way ANOVA) and for PrL → BA (*p < 0.05, post-hoc Holm-Sidak’s multiple comparisons test after two-way ANOVA).