Table 4.
Relationship between genetic variants in circadian rhythm genes and posttraumatic stress symptoms in individuals following sexual assault (SA, n = 274) and major thermal burn injury (MThBI, n = 68) trauma.
| SA cohort | MThBI cohort | |||||
|---|---|---|---|---|---|---|
| Gene name | SNP | Interaction | p-value (All)* | p-value (AA)* | p-value (All)* | p-value (AA)* |
| RORB | rs7022435 | – | 0.641 | 0.112 | NA | NA |
| BMAL1 | rs969485 | – | 0.663 | 0.546 | 0.351 | 0.443 |
| RORA | rs4774388 | – | 0.579 | 0.630 | 0.601 | 0.928 |
| RORA | rs4774388 | sex | – | – | 0.505 | 0.899 |
| NPAS2 | rs12622050 | distress | 0.171 | 0.131 | 0.296 | 0.333 |
| TEF | rs5758324 | distress | 0.020 | 0.040 | 0.020 | 0.013 |
| TEF | rs738499 | distress | 0.233 | 0.421 | 0.524 | 0.206 |
| TEF | rs738499 | FKBP5 | 0.995 | 0.665 | 0.485 | 0.909 |
Only genetic variants shown to be associated with posttraumatic stress symptoms following motor vehicle collision (MVC) were assessed in these cohorts.
*
p-value generated via repeated measures mixed models (6 week, 6 months, 1 year), adjusted for age, sex, emergency department enrollment site, education, and time following sexual assault (SA) or major thermal burn injury (MThBI). AA, African American individuals only; NA, genetic variant not available.
Bold values indicate significance at the p < 0.05 threshold.