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. 2018 Nov 21;8:17174. doi: 10.1038/s41598-018-33873-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Targeting of NCL with the AS1411 aptamer inhibits proliferation of pre-B ALL cells. (a) FACS analysis for cell surface NCL in ICN13 cells treated with 15 µM AS1411 or control CRO26. (b,c) Treatment with the indicated concentrations of AS1411 or control CRO26 aptamers for 48 hr in the absence of stroma. (b) total cell number, (c) viability. One experiment of two with different sources of aptamers. Values- mean ± S.E. n.s., not significant, ^*p < 0.05, ^**p < 0.01, ^***p < 0.001. One-way ANOVA.