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. 2018 Nov 15;9:2616. doi: 10.3389/fimmu.2018.02616

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Copyright © 2018 Lancman, Arinsburg, Jhang, Cho, Jagannath, Madduri, Parekh, Richter and Chari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of daratumumab interference with the indirect antiglobulin test (IAT). (A) Negative IAT in a sample without RBC alloantibodies or daratumumab. (B) Positive IAT due to RBC alloantibodies in the sample. (C) Positive IAT due to interference from daratumumab, which binds to CD38 on RBCs and causes agglutination with the addition of Coombs reagent.