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. 2018 Nov 15;9:1276. doi: 10.3389/fphar.2018.01276

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Copyright © 2018 Shi, Chen, Xie, Yang, Liu, Dai and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological examination of mouse lung tissue. (A) HE staining of mouse lung tissue and viewed under the light microscope (× 100,scale bars = 1000 μm or × 400,scale bars = 250 μm). (B) Apoptosis in mouse lung tissue detected by TUNEL assay and histogram of the apoptosis rate of cells in mice lung tissue amongst control, COPD and COPD+celastrol groups (× 200, scale bars = 500 μm or × 400, scale bars = 250 μm. Blue arrow indicates the site of inflammation in (A); the condensed and fragmented nuclei are indicated with arrows in (B). Values are expressed as the mean ± SEM (n = 5); ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 with respect to the control group; ^#p < 0.05, ^##p < 0.01 with respect to the COPD group.