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. 2018 Nov 15;9:1276. doi: 10.3389/fphar.2018.01276

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Copyright © 2018 Shi, Chen, Xie, Yang, Liu, Dai and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Celastrol inhibited the Ednrb/Kng1 signaling pathway. (A) Detection of mRNA expression levels of Ednrb and Kng1 in Beas-2B cells by q-PCR. (B) Detection of mRNA expression levels of Ednrb and Kng1 in mouse lung tissue by q-PCR. (C) Detection of protein expression levels of Ednrb and Kng1 in Beas-2B cells by western blotting. (D) Detection of protein expression levels of Ednrb and Kng1 in mouse lung tissue by western blotting. Each result was derived from three independent experiments. Values are expressed as the mean ± SEM (n = 3) ^**p < 0.01, ^***p < 0.001 with respect to the control group; ^#p < 0.05, ^##p < 0.01 with respect to the CSE group or COPD group.