Supplementary Table 1. Standardized regression coefficients for log-transformed IL-6 by multiple regression analysis for each covariate.
| Model 1 |
Model 2 |
|||
|---|---|---|---|---|
| β (SE) | P-value | β (SE) | P-value | |
| Age (per 10 years) | 0.004 | < 0.001 | 0.038 | < 0.001 |
| (0.001) | (0.004) | |||
| Sex (female/male) | −0.064 | < 0.001 | −0.042 | 0.003 |
| (0.008) | (0.010) | |||
| BMI (per 1 kg/m2) | 0.017 | < 0.001 | 0.013 | < 0.001 |
| (0.001) | (0.001) | |||
| Work schedule | ||||
| Regular work | Ref | Ref | ||
| Shift work without night work | 0.005 | 0.79 | 0.004 | 0.82 |
| (0.020) | (0.020) | |||
| Shift work with night work | 0.002 | 0.83 | 0.002 | 0.83 |
| (0.008) | (0.009) | |||
| Only night work | 0.078 | < 0.001 | 0.058 | 0.01 |
| (0.023) | (0.023) | |||
| Lifestyle | ||||
| Smoking status | ||||
| Never | Ref | Ref | ||
| Former | 0.013 | 0.27 | −0.005 | 0.69 |
| (0.011) | (0.012) | |||
| Current | 0.052 | < 0.001 | 0.041 | < 0.001 |
| (0.008) | (0.008) | |||
| Frequency of alcohol drinking | ||||
| None | Ref | Ref | ||
| Sometimes | −0.012 | 0.12 | −0.012 | 0.15 |
| (0.008) | (0.008) | |||
| Daily | −0.011 | 0.21 | −0.046 | < 0.001 |
| (0.009) | (0.010) | |||
| Physical exercise | ||||
| None | Ref | Ref | ||
| Light exercise more than once a week | −0.008 | 0.39 | −0.021 | 0.02 |
| (0.009) | (0.009) | |||
| Heavy exercise once or twice a week | −0.045 | 0.002 | −0.039 | < 0.001 |
| (0.012) | (0.012) | |||
| Heavy exercise more than three times a week | −0.081 | 0.002 | −0.074 | 0.001 |
| (0.022) | (0.023) | |||
| Socioeconomic status | ||||
| Years of education (12 or less/ more than 12) | 0.039 | < 0.001 | 0.005 | 0.47 |
| (0.007) | (0.008) | |||
| Hours worked per week | ||||
| Less than 40 | Ref | Ref | ||
| 41–60 | −0.007 | 0.34 | −0.009 | 0.25 |
| (0.007) | (0.008) | |||
| 61 or more | 0.006 | 0.72 | 0.012 | 0.47 |
| (0.016) | (0.016) | |||
| Annual household income (million JPY/year) | ||||
| More than 800 | Ref | Ref | ||
| 300–799 | 0.004 | 0.61 | 0.047 | < 0.001 |
| (0.007) | (0.008) | |||
| Less than 299 | −0.016 | 0.21 | 0.057 | < 0.001 |
| (0.012) | (0.014) | |||
| Laboratory data | ||||
| LDL-C (per 10mg/dl) | 0.010 | < 0.001 | 0.002 | 0.20 |
| (0.001) | (0.001) | |||
| HbA1c (per 1%, NGSP) | 0.070 | < 0.001 | 0.019 | 0.005 |
| (0.006) | (0.007) | |||
| Job stress | ||||
| Effort-Reward Balance | −0.001 | 0.96 | −0.015 | 0.48 |
| (0.019) | (0.022) | |||
Model 1: unadjusted
Model 2: includes age, sex, years of education, hours worked per week, annual household income, BMI, Laboratory data (LDL-C, HbA1c), job stress
Abbreviations: β, regression coefficients; LDL-C, low-density lipoprotein cholesterol; ref, reference; SE, standard error