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. 2018 Nov 15;9:964. doi: 10.3389/fneur.2018.00964

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Copyright © 2018 Madathil, Wilfred, Urankar, Yang, Leung, Gilsdorf and Shear.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in Iba-1 immunoreactivity in sub cortical white matter (SCWM) at 72 h post injury. Few scattered microglia with migrating morphology (long processes) were found in sham rat's SCWM (a,b). Numerous, hypertrophied microglia were found in the SCWM following either single (c,d) or repeated concussions (e,f). SC: single concussion, RC: repeated concussion, CX: cortex, HP: hippocampus, SCWM: subcortical white matter. Scale bar in e (for left panel) = 200 μm and in f (for right panel) = 50 μm.