Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 15;12:759. doi: 10.3389/fnins.2018.00759

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Lee, Wang, Hitchcock, Loh, Whittaker, Kim, Aiken, Kokikian, Dell’Angelica, Colwell and Ghiani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Loss of BLOC-1 does not impact the neuronal output of the suprachiasmatic nucleus (SCN) in vitro. (A,B) The rhythms in spontaneous firing rate (SFR) of SCN neurones were examined in wild-type (WT) and pallid mice using extracellular electrophysiological recordings in a brain slice preparation during the day and the night. ZT, Zeitgeber Time. The SFR were recorded and the results averaged to give a profile of (A) the day-time (ZT2–11; 29–33 neurones/h from 4 animals/genotype) and of (B) the night-time (ZT13–23; 20–24 neurones/h from 3 animals/genotype) firing rate. Data points are the mean ± SEM. Two-way ANOVA followed by Holm–Sidak’s multiple comparisons test was used to evaluate the effects of genotype and time, and their interaction revealed no significant differences during the day or the night (Supplementary Table 2).