. 2018 Nov 15;9:1604. doi: 10.3389/fphys.2018.01604

Table 2.

Meta-analysis results of the miR-146a rs3027898 and miR-499a rs3746444 polymorphisms with genetic susceptibility to rheumatoid arthritis.

Variables	N	C vs. G			CC vs. GG			GC vs. GG			GC/CC vs. GG			CC vs. GC/GG
		OR (95% Cl)	P_h	I²(%)	OR (95% Cl)	P_h	I²(%)	OR (95% Cl)	P_h	I²(%)	OR (95% Cl)	P_h	I²(%)	OR (95% Cl)	P_h	I²(%)
miR-146a G > C
Caucasian	6	0.92 (0.80–1.05)	0.486	0.0	0.88 (0.64–1.20)	0.692	0.0	0.89 (0.74–1.06)	0.545	0.0	0.89 (0.75–1.05)	0.476	0.0	0.93 (0.69–1.26)	0.772	0
Asian	2	0.98 (0.86–1.11)	0.743	0.0	0.94 (0.72–1.23)	0.915	0.0	0.95 (0.74–1.23)	0.754	0.0	0.95 (0.75–1.21)	0.896	0.0	0.98 (0.81–1.19)	0.593	0
All ethnicity	8	0.95 (0.86–1.04)	0.660	0.0	0.91 (0.75–1.12)	0.870	0.0	0.91 (0.78–1.05)	0.740	0.0	0.91 (0.79–1.04)	0.690	0.0	0.97 (0.82–1.14)	0.896	0

		C vs. T			CC vs. TT			TC vs. TT			TC/CC vs. TT			CC vs. TC/TT
		OR (95% Cl)	P_h	I²(%)	OR (95% Cl)	P_h	I²(%)	OR (95% Cl)	P_h	I²(%)	OR (95% Cl)	P_h	I²(%)	OR (95% Cl)	P_h	I²(%)

miR-499a T > C
Caucasian	2	1.64 (1.28–2.11)	0.740	0.0	2.06 (1.06–3.97)	0.973	0.0	1.95 (1.40–2.71)	0.951	0.0	1.96 (1.43–2.69)	0.977	0.0	1.52 (0.81–2.86)	0.906	0.0
Asian	3	1.04 (0.86–1.25)	0.351	4.4	1.03 (0.53–2.01)	0.598	0.0	1.05 (0.85–1.29)	0.293	18.5	1.05 (0.85–1.29)	0.312	14.2	1.03 (0.53–2.01)	0.592	0
All ethnicity	5	1.22 (1.05–1.42)	0.035	61.2	1.46 (0.92–2.32)	0.558	0.0	1.26 (1.05–1.50)	0.016	67.1	1.26 (1.07–1.50)	0.011	69.2	1.26 (0.80–1.99)	0.790	0.0

CI, confidence interval, OR, odds ratio, I² = the variation in OR attributable to heterogeneity.