Figure 2.

Effect of Different Concentrations of Atorvastatin on Tube Formation and Cell Proliferation. a) Dose dependent effect of atorvastatin on proliferation of the tubular structure. Atorvastatin at 5 μM and 10 μM significantly reduced number of connected tubes. Expression of PECAM-1 protein demonstrated reduced tub formation in treated group specially at 5 and 10 µM. Scale bar is 100 μm. b) The MTT assay of HUVECs seeded on top of fibrin. The proliferation rate was inhibited by all concentration, especially at 5 and 10μM. Data are expressed as mean ± SD of three independent experiments. *P<0.05, **P<0.01.