Table 1.
Effect of RESV on the levels of cerebral lipid peroxidation products and antioxidant activity in experimental neonatal rats.
Group | GPx (µg/mg protein) | SOD (U/mg protein) a | CAT (U/mg protein) b | MDA (nmol/mg protein) |
---|---|---|---|---|
Sham-control | 8.53 ± 1.05 | 3.45 ± 0.28 | 62.80 ± 5.05 | 0.48 ± 0.07 |
HI induced | 5.22 ± 0.63a** | 2.55 ± 0.18a** | 51.24 ± 4.46a** | 0.82 ± 0.04a** |
RESV 20 + HI | 6.49 ± 0.5b* | 3.05 ± 0.15b* | 55.23 ± 6.34b* | 0.69 ± 0.06b* |
RESV 40 + HI | 7.78 ± 0.75b** | 3.25 ± 0.15b** | 59.74 ± 6.34b** | 0.57 ± 0.07b** |
Data are expressed as the mean ± standard deviation (SD). p value: *p < 0.05, **p < 0.01, Where ‘a’ represent the comparison with the sham control group; ‘b’ represent the comparison with the HI-insulted group.
aU (One unit) represents the amount of SOD required for inhibiting 50% of O2 − at 550 nm.
bU (One unit) represents the amount of CAT required for inhibiting 50% of H2O2 at 405 nm.
RESV: Resveratrol; HI: hypoxia-ischemia; U: units; SOD: superoxide dismutase; CAT: catalase; GSH: glutathione; MDA: malondialdehyde.