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Node-splitting results for outcomes. p < .05 indicates inconsistency between direct and indirect evidence. A: placebo; B: bosentan; C: ambrisentan; D: macitentan; E: sitaxsentan; F: berapost; G: treprostinil; H: epoprostenol; I: ambrisentan + tadalafil; J: vardenafil; K: tadalafil; L: sildenafil; M: sildenafil + bosentan; N: sildenafil + epoprostenol; O: iloprost + bosentan; P: bosentan + epoprostenol; Q: riociguat + sildenafil; R: riociguat; S: selexipag.
