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. 2018 Nov 15;25(1):1898–1909. doi: 10.1080/10717544.2018.1523257

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Heat plots of CI change, clinical worsening, hospitalization and WHO FC improvement. The area of the gray squares displays the contribution of the direct estimate in the design shown in the column to the network estimate in the design shown in the row. The colors are associated with the change in inconsistency between direct and indirect evidence. Blue colors indicate a decrease and warm colors indicate an increase (the stronger the intensity of the color, the stronger the change). A: placebo; B: bosentan; C: ambrisentan; D: macitentan; E: sitaxsentan; F: berapost; G: treprostinil; H: epoprostenol; I: ambrisentan + tadalafil; J: vardenafil; K: tadalafil; L: sildenafil; M: sildenafil + bosentan; N: sildenafil + epoprostenol; O: iloprost + bosentan; P: bosentan + epoprostenol; Q: riociguat + sildenafil; R: riociguat; S: selexipag.