Table 1.
Surface under the cumulative ranking curve (SUCRA) results for outcomes.
| Treatment | 6MWD change | WHOFC improvement | BDS change | CI change | mPAP change | mRAP change | PVR change | Clinical worsening | Hospitalization | Death | SAEs | Withdrawal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Placebo | 0.0950 | 0.1247 | 0.0524 | 0.1601 | 0.0792 | 0.2807 | 0.2001 | 0.1298 | 0.2215 | 0.3068 | 0.5331 | 0.4537 |
| Bosentan | 0.5731 | 0.4197 | 0.5903 | 0.7154 | 0.6424 | 0.7139 | 0.8170 | 0.6550 | 0.5396 | 0.5518 | 0.3437 | 0.6639 |
| Ambrisentan | 0.5679 | 0.3266 | 0.5031 | – | – | – | – | 0.6130 | 0.4268 | 0.6676 | – | 0.6603 |
| Macitentan | 0.3047 | 0.8385 | – | – | – | – | – | 0.3159 | 0.4533 | 0.2015 | 0.7147 | 0.5359 |
| Sitaxsentan | 0.3808 | 0.3909 | – | 0.4171 | 0.4455 | 0.5105 | 0.0139 | 0.6706 | 0.7511 | 0.4933 | 0.5162 | 0.6994 |
| Berapost | 0.3678 | 0.2442 | 0.3283 | 0.2196 | 0.1880 | 0.4511 | – | 0.4688 | – | 0.4928 | 0.8179 | 0.1360 |
| Treprostinil | 0.4376 | 0.5017 | 0.8771 | 0.4501 | 0.1198 | 0.4494 | 0.2346 | 0.2369 | 0.2237 | 0.4417 | 0.6964 | 0.2723 |
| Epoprostenol | 0.6204 | 0.9667 | – | 0.6105 | 0.6862 | 0.6160 | – | – | – | 0.7404 | 0.1614 | 0.3889 |
| Ambrisentan + tadalafil | 0.8513 | 0.5071 | – | – | – | – | – | 0.8467 | 0.8411 | 0.5404 | – | 0.5432 |
| Vardenafil | 0.8172 | 0.3100 | 0.8802 | 0.4892 | 0.5631 | 0.5595 | – | 0.8312 | – | 0.8405 | 0.6851 | 0.9813 |
| Tadalafil | – | 0.4990 | – | – | – | – | – | 0.3646 | 0.5097 | 0.4045 | – | – |
| Sildenafil | 0.5991 | 0.7901 | – | 0.5518 | 0.4654 | 0.4360 | 0.4664 | 0.4411 | 0.6587 | 0.2514 | 0.2311 | 0.3664 |
| Sildenafil + bosentan | 0.7703 | 0.7008 | – | – | – | – | – | – | – | 0.3453 | 0.4775 | 0.2482 |
| Sildenafil + epoprostenol | 0.3194 | – | – | – | – | – | – | – | – | 0.9712 | 0.3505 | 0.6923 |
| Iloprost + bosentan | 0.7098 | – | – | – | 0.9490 | – | 0.9931 | 0.9034 | – | 0.7201 | 0.5958 | 0.6885 |
| Bosentan + epoprostenol | 0.3651 | – | – | 0.9900 | 0.9338 | 0.7909 | – | – | – | 0.4084 | 0.3396 | 0.2066 |
| Riociguat + sildenafil | – | – | – | – | – | – | – | – | – | 0.4603 | 0.1951 | 0.3393 |
| Riciguat | 0.3183 | 0.3799 | 0.2687 | 0.3375 | 0.4275 | 0.5838 | 0.5608 | 0.1910 | 0.4845 | 0.4999 | 0.6490 | 0.5026 |
| Selexipag | 0.4022 | – | – | 0.5588 | – | 0.1083 | 0.7141 | 0.3320 | 0.3899 | 0.1623 | 0.6929 | 0.6212 |
6MWD: 6 minutes walking distance; FC: functional class; BDS: Borg dyspnea score; CI: cardiac index; mPAP: mean pulmonary artery pressure; mRAP: mean right arterial pressure; PVR: pulmonary vascular resistance; SAEs: severe adverse event. The bolded value is top three SUCRA under each endpoints.