Table 1.
Mouse Strain Survival After Infection With Mouse-Adapted Ebola Virus or Reverse Genetics–Derived Mouse-Adapted Ebola Virus
| Virus dose | ||||||||
|---|---|---|---|---|---|---|---|---|
| MA-EBOV | rgMA-EBOV | |||||||
| Mouse strain | 10 FFU | 1000 FFU | 10 FFU | 1000 FFU | ||||
| Survival | Time to death, days after infection | Survival | Time to death, days after infection | Survival | Time to death, days after infection | Survival | Time to death, days after infection | |
| C57BL/6N | 44%a | 7–9 | 10% | 7–9 | 20% | 7–15 | 90% | 7 |
| C57BL/6J | 60% | 7–9 | 90% | 7 | 90% | 8 | 100% | NA |
| C57BL/6NCr | 30% | 7–13 | 70% | 7–9 | 60% | 7–9 | 88%a | 7 |
| BALB/c | 0% | 3–7 | 10% | 5–7 | 10% | 4–7 | 40% | 6–7 |
| 129 | 0% | 5–7 | 10% | 6–8 | 0% | 6–7 | 0% | 6–8 |
| CD-1 | 0% | 5–7 | 0% | 5–6 | 0% | 5–7 | 0% | 5–6 |
Abbreviations: FFU, focus-forming unit; rgMA-EBOV, reverse genetics–derived mouse-adapted Ebola virus; MA-EBOV, mouse-adapted Ebola virus; NA, not applicable
an = 9 in these 2 groups only; all others: n = 10.