Table 3.

Detection of Synergy in Blocking Cell Entry of Ebola Virus–Like Particles

Drug 1	Top Concentration, μM	Drug 2	Top Concentration, μM	Log Synergy Volumea	Experiments, No.b
Apilimod	0.1	Bepridil	10	11.98	2
Sertraline	10	Toremifene	5	6.57	2
Apilimod	0.1	Toremifene	5	6.00	2
Bepridil	10	Toremifene	5	3.58	2
Clomiphene	5	Clomiphenec	5	0.63	3

Four drug combinations were tested for ability to block Ebola virus–like particle entry, and synergistic effects were determined using MacSynergy software, as described in the Supplementary Methods.

^aMacSynergy scores are given at the 99.9% confidence interval. Log synergy volume is averaged over the number of experiments.

^bTwo or 3 plates were analyzed in each experiment.

^cThe self-cross pair clomiphene/clomiphene was used as an expected negative control.